Holly Valance - Nika Volek (3/22 episodes).Al Sapienza - Philly Falzone (4/22 episodes).John Heard - Frank Tancredi (5/22 episodes).Camille Guaty - Maricruz Delgado (5/22 episodes).Silas Weir Mitchell - Charles 'Haywire' Patoshik (6/22 episodes).Joseph Nunez - Manche Sanchez (6/22 episodes).Michelle Forbes - Samantha Brinker (7/22 episodes).Matt DeCaro - Roy Geary (8/22 episodes).Lane Garrison - David 'Tweener' Apolskis (9/22 episodes).DuShon Monique Brown - Katie Welch (11/22 episodes).Mac Brandt - Mack Andrews (13/22 episodes).Danny McCarthy - Daniel Hale (13/22 episodes).Patricia Wettig - Caroline Reynolds (14/22 episodes).

Christian Stolte - Keith Stolte (17/22 episodes).Muse Watson - Charles Westmoreland (18/22 episodes).Frank Grillo - Nick Savrinn (18/22 episodes).Phillip Edward Van Lear - Louis Patterson (19/22 episodes).

Stacy Keach - Henry Pope (20/22 episodes).

Rockmond Dunbar - Benjamin Miles 'C-Note' Franklin (16/22 episodes).

Robert Knepper - Theodore 'T-Bag' Bagwell (19/22 episodes).

Paul Adelstein - Paul Kellerman (19/22 episodes).

Sarah Wayne Callies - Sara Tancredi (22/22 episodes).

Wade Williams - Brad Bellick (22/22 episodes).

Peter Stormare* - John Abruzzi (17/22 episodes).

Marshall Allman - Lincoln 'LJ' Burrows Jr (11/22 episodes).

Amaury Nolasco - Fernando Sucre (22/22 episodes).

Robin Tunney - Veronica Donovan (22/22 episodes).

Wentworth Miller - Michael Scofield (22/22 episodes).

Dominic Purcell - Lincoln Burrows (22/22 episodes).

Paul Adelstein and Robert Knepper were credited as guest stars before episode 3 Peter Stormare was credited as a guest star after episode 13 and Rockmond Dunbar was credited as a guest star before episode 14.

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